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It mainly occurs with oral drugs

The laboratory where Massachusetts General Hospital works is one of the halcyon sites where the technique is used to study hormones

However, when the extent of hepatocyte damage exceeds their capacity for self-replication, other liver cells are activated to undergo dedifferentiation or transdifferentiation, thereby compensating for the lost tissue

Scott Greenberg, an integrative physician experienced in EDS, notes that if an EDS patient shows signs of joint degeneration or lots of dislocations, he adds stem cell therapy to the treatment plan (often in combination with PRP and prolotherapy)