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J Neurosci 19:562569 Dringen R, Gutterer JM, Gros C, Hirrlinger J (2001) Aminopeptidase N mediates the utilization of the GSH precursor CysGly by cultured neurons

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Future studies using melatonin-competent mice, genetic validation of receptor independence, and time-of-day dosing paradigms will be critical to determine whether the melatoninglutathione axis can be exploited therapeutically to treat asthma

It is commonly accepted that reaction of sulfenic acids with reduced glutathione (GSH) or H 2 S prevents cysteine overoxidation

Overall, it is clear that NAD + fluxes within the cell are complex and dynamic, but the concentrated levels of NAD + in the mitochondria indicate major impacts of the cofactor in this organelle in particular, which will be summarized below

Jun 2009;24(6):1908-1918