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Gene profiling studies showed that GHK upregulates the expression of 54 genes known as tumor suppressors while simultaneously downregulating 48 oncogenic genes (Pickart et al., 2018)

painless-DPN p=0.048

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Animal Model Evidence The systemic evidence base is entirely preclinical: Pulmonary fibrosis (mouse model): Intraperitoneal GHK-Cu at 0.2-20 micrograms/g/day protected against bleomycin-induced lung fibrosis by inhibiting TGF-beta1/Smad signaling and reducing oxidative stress (PMID 31809714)