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10.1007/s13346-018-00613-y 6 BolamanZ.KadikoyluG.YukselenV.YavasogluI.BarutcaS.SenturkT

doi: 10.1017/S0007114517001593

For long-term maintenance, most healthcare providers recommend one B12 injection every 4 to 12 weeks

The primary preclinical evidence comes from mouse studies showing reduced body weight and adipose mass in diet-induced obese mice (2018), improved grip strength in aged mice (2024), and beneficial microbiome changes when combined with caloric restriction (2022)

Nat Chem Biol (2019) 15:113747