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The TPH2 gene is located on chromosome 12q21.1 and is composed of 13 exons that encode a protein (tryptophan 5-hydroxylase 2) of 490 amino acids

A longer-term concern that has received attention in the cardiology literature involves trimethylamine N-oxide (TMAO)

As physicians, our goal is to rely on safe, evidence-based treatments

The protocol is not a quick fix

Following fixation, hearts were embedded in paraffin and 5 m sections were mounted onto treated slides, and stained with hematoxylin and Eosin (H&E) and co-stained with Massons trichrome

Key takeaways There is no quality scientific evidence to suggest that coffee enemas provide health benefits