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The stability of a partially engaged state, the stability of the fully bound state (which is competent for G protein activation) and the height of the energy barrier separating these two states could all be affected by changes at Gly10 of GLP-1 or Gly4 of exendin-4 (Fig

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Future generations of incretin agonists may be able to maintain the reduction in blood glucose and body weight while minimizing these off-target effects