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However, for those with dietary restrictions or absorption issues, supplementation may be necessary

(1996) reported the analog was 1.5-2x more potent than equimolar IGF-1 in catabolic rat models, and broader pharmacology literature places it at roughly 3x potency overall

doi: 10.1089/ars.2010.3496 97 GhatiA.DamP.TasdemirD.KatiA.SellamiH.SezginG

Recently Novo Nordisk announced the initiation of REDEFINE 4, a phase 3 trial comparing CagriSema 2.4 mg with Lillys Zepbound 15 mg evaluating weight loss after 72 weeks in 800 obese patients non-diabetic and is expected to be completed by October 2025 (NCT06131437)

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While not a 1-to-1 substitution for anti-obesity drugs, fiber-rich foods work similarly and also keep you fuller for longer