10.1186/s13075-024-03274-0 75 Ortiz-AndradeR.Araujo-LenJ
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Although we were unable to assess blood drugs levels in the TriNetX database, the consistent reduction in MAKEs observed in steroid, tacrolimus and cyclosporine subgroups provides indirect reassurance of the safety of GLP-1 RAs in KRTs and regardless of the specific immunosuppressive regimen
BPC-157 (Body Protection Compound-157) is a synthetic 15-amino-acid peptide derived from a protein found in human gastric juice
Cognitive Decline and Neurodegenerative Conditions Cognitive decline and neurodegenerative conditions show substantial preclinical evidence across multiple pathologies: Stroke models: BPC-157 given during reperfusion counteracted neuronal damage and produced full functional recovery in spatial memory, motor coordination, and balance tests Parkinsons models: MPTP-induced models showed reduced motor symptoms (tremor, rigidity, akinesia), protection of nigrostriatal dopaminergic neurons, and near-complete prevention of mortality Multiple sclerosis models: Cuprizone-induced demyelination resulted in significantly less brain damage and reduced clinical abnormalities when BPC-157 was given in drinking water or intragastrically Traumatic brain injury: Falling weight model studies demonstrated reduced hemorrhage, decreased brain lacerations and edema, and improved early outcomes These diverse models share common mechanisms
Older adults, those with certain digestive conditions, and people who take some common medications may get very little from an oral pill, no matter how high the dose
