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The following adverse reactions have been associated with the abrupt discontinuation of the individual components of QSYMIA: For topiramate, abrupt discontinuation has been associated with seizures in patients without a history of seizures or epilepsy [see Warnings and Precautions (5.9)]

Hypertensive Emergency Acutely elevated blood pressure with signs of target organ damage (2)

Maintain adequate fluid intake, especially if experiencing vomiting or diarrhoea

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Less weight means less mechanical pressure on joints