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Orthogonal validation of NMR fragment hit 27 Encouraged by the relatively high binding affinity of compound 27 compared to expectations for fragments, we synthesised a series of analogues to explore the effect of modifying both the sulfonic acid and the ethoxy substituents on binding affinity (Table 1)

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Buffered NAD+ ships with a pH stabilizer (most commonly Tris) that brings the reconstituted solution closer to physiological pH (~7-8.5), while unbuffered NAD+ reconstitutes acidic (~pH 3-4) and is more often associated with injection-site stinging

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Skip to the end of the images gallery Skip to the beginning of the images gallery Be the first to review this product 34.99 Availability: Out of stock SKU 9780201379662 Nordic Labs AOD9604 5mg **Research-grade compounds for scientific and laboratory use only