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First, there needs to be a determination if the deficiency actually exists or if there is a medical need for it

Glutathionylation, a key mechanism of post-translational modification of proteins, involves the formation of a disulfide bridge between GSH and an available protein cysteine thiol

J Pharmacol Exp Ther 311:99108 Clancy RM, Levartovsky D, Leszczynska-Piziak J, Yegudin J, Abramson SB (1994) Nitric oxide reacts with intracellular glutathione and activates the hexose monophosphate shunt in human neutrophils: evidence for S-nitrosoglutathione as a bioactive intermediary

However, the hyperthermia-induced heat shock response and low Fenton reaction efficiency limited its clinical application

Insulin resistance in brain alters dopamine turnover and causes behavioral disorders

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