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However, under pathological states such as chronic inflammation or DM, HDL-C particles are prone to structural remodeling and functional impairment, potentially adopting a pro-inflammatory phenotype and thereby losing their protective capacity ( Table 1 )

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Cells were cultured in Dulbeccos modified Eagles medium high glucose (4.5 g/L

In a separate study, single-cell suspensions of patient-derived organoids were introduced directly into the ducts of the murine pancreas