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Thats a meaningful difference when something is going directly into your bloodstream

For the KLOW context specifically, it is worth stressing again that the ophthalmic Phase 2 data the most solid human evidence in the T4 story concern eye drops delivering the full protein to the ocular surface

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At the low end (20 units): 0.40 mg per injection per peptide

PMID 2137911 Injection site pharmacokinetics - Injection site can affect peptide and small-protein PK through regional blood flow and pre-systemic proteolysis