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Many patients in the SURPASS trials achieved HbA1c below 5.7 percent, which is the threshold for normal glycemia

As a protein building block, glycine supports muscle protein synthesis at a time when dietary protein intake often decreases and catabolic pressures increase

This effect allows patients to adopt healthier eating patterns without the psychological strain of excessive hunger

After 36 weeks of tirzepatide-driven weight loss, participants were randomized to continue tirzepatide or switch to placebo