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IGF-1 is primarily synthesized in the liver, and then binds to specific receptors of cellular structures inside the bodymost notably, in bones, muscle, and cartilage

(2017) found phylum-level variations in the gut microbiota of individuals with CAD, with a lower proportion of Bacteroidetes and a higher proportion of Firmicutes (Cui et al., 2017)

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The evolution of this phenomenon results in the pathological increase of the normal excavation of the optic papilla, which eventually results in a serious vision deficit