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Oral administration of AVE3085 for 7 days increases eNOS expression and activity, reverse eNOS uncoupling, reduces oxidative stress and improve endothelial function in diabetic mice (Yang et al., 2011)

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This inconsistency may have contributed to the observed heterogeneity

This manufacturing quality variation means apparent non-response could actually reflect product problems rather than peptide ineffectiveness

The review also discusses renal targets and focuses on CKD progression, including associated biochemical pathways