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The main ingredient, berberine, can cause digestive side effects like diarrhoea, constipation, and an upset stomach

The body naturally converts this lipid into 2-AG, a powerful internal endocannabinoid

In the last decade, studies on the condition of BBB in neurodegenerative diseases, including ALS, have demonstrated the presence of vascular disruption, a condition that could theoretically favour the entry of drugs into brain regions affected by neurodegeneration

Clinical evidence suggests that discontinuing the medication often leads to weight regain, as the appetite-suppressing effects wear off

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