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Pickart and colleagues (Nature, 1980, PMID 7453802) reported facilitated copper uptake into cultured cells, and Simon and colleagues (Life Sci, 2000, PMID 11045606) reported upregulated MMP-2 alongside its tissue inhibitors in fibroblast culture
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Time needed for improvement ranges from a few days to several weeks, depending on the individual
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However, full benefits typically appear after 3 to 6 weeks of consistent treatment, as tissue repair and inflammation reduction take place gradually
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