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In the STEP 1 phase-3 trial, once-weekly semaglutide 2.4 mg achieved about ~15% of total body weight in mean weight loss over 68 weeks, substantially more than placebo, with gastrointestinal symptoms the most common adverse events [6] [7]
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But it still happens, and knowing this prevents the common mistake of thinking the medication has "stopped agreeing" with you
Clinical monitoring and patient safety advice includes: Gastrointestinal symptoms : Patients should report severe or persistent nausea, vomiting, or abdominal pain, which may indicate pancreatitis (a warning in tirzepatide labeling) or require dose adjustment
Think in weeks and patternschanges in appetite, sleep, strength, lab values, and how your clothes fit are all signs of progress long before the mirror shows it
Enhanced quality of life: Losing weight with semaglutide can lead to increased energy levels, better mobility, and an overall improvement in physical and emotional well-being
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