A meta-analysis covering over 28,000 patients found that while the overall rate of GI adverse events was similar (approximately 5253% of patients in both groups), serious adverse events occurred somewhat more frequently with higher tirzepatide doses (5.37% at 1015 mg) compared to semaglutide (2.8%)
According to a small study, after GI symptoms, fatigue was the second-most common side effect, affecting 6.3% of patients
Establish routine : Attempt bowel movements at consistent times, particularly after meals when the gastrocolic reflex is strongest
At Restore, our clients have access to ongoing clinical care with Nurse Practitioners and an in-studio Registered Nurse team to help track progress
More serious but less common side effects to watch for at this dose include acute pancreatitis (symptoms: severe abdominal pain radiating to the back, nausea, vomiting), gallbladder problems (symptoms: sudden pain in the upper right abdomen, fever, jaundice), and significant hypoglycemia if combined with certain diabetes medications
Symptoms often appear early in treatment or after dose increases
