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Practical takeaway: if weight loss is the goal, Wegovy or compounded semaglutide may be the appropriate treatment not off-label Ozempic

This is shown in respiratory chain complex enzyme activity (176) and oxidative stress (measured by total antioxidant capacity and plasma 15-F2t-isoprostane) (177)

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This mechanistic complexity, coupled with the translational gap between animal models and clinical practice, has repeatedly undermined single-target strategies and continues to limit the development of effective therapies

Compared to receiving no other treatment, semaglutide added one QALY at a cost of $27,000