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ECM thickens the glomerular basement membrane and promotes renal fibrosis

Individuals with any of the following have a higher baseline risk for venous thromboembolism and may therefore carry an elevated risk if additional factors occur during treatment: Obesity or severe excess weight Recent major surgery or hospitalization Prolonged immobility or bed rest A personal or family history of blood clots or inherited thrombophilia Active cancer Use of estrogen-containing medications, such as some birth control or hormone therapy Pregnancy or the postpartum period Older age and reduced mobility Varicose veins or chronic vascular disease Significant cardiovascular disease, diabetes with vascular complications, or uncontrolled high blood pressure Can Pre-Existing Conditions Make Clot Risk Worse on Mounjaro

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Some studies have found no significant reduction in TPOAb levels in HT patients after vitamin D supplementation compared to the placebo group