This is why most medications delivered through standard transdermal patches are small, lipophilic compounds such as nicotine or certain hormones
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[11] Apart from drug-drug interactions, anabolic steroids may affect laboratory tests: testosterone therapy can decrease levels of thyroxine-binding globulin, resulting in lower total T (thyroxine) readings and higher T uptake, although free thyroid hormone levels remain unchanged and clinical hypothyroidism does not occur
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Of note, ectopic ACTH secretion is common in lung carcinoid tumors but is not always associated with overt cortisol excess ( 68 Ga-labeled somatostatin analog uptake in the pituitary gland, along with the elevated serum cortisol and ACTH levels at baseline, suggests that this patient had some degree of cortisol excess at baseline