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In vivo RNAi-mediated alpha-synuclein silencing induces nigrostriatal degeneration
Neurogastroenterol Motil 30(7):e13313-e Coskun T, Sloop KW, Loghin C, Alsina-Fernandez J, Urva S, Bokvist KB et al (2018) LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: from discovery to clinical proof of concept
NRF2 provides a protective effect in melanocytes in response to both UV irradiation and oxidative stress 30,31 , through transcriptional upregulation of the antioxidant response element (ARE) genes including Superoxide dismutase-1 (SOD-1), Glutathione peroxidase-1 (GP-1), Glutathione reductase-1 (GR-1), Catalase and Heme oxygenase-1 (HO-1) 38,39,40
L-carnitine promotes normal heartbeat and can alleviate angina symptoms by increasing blood oxygen levels and keeping blood vessels clear