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Mice Wfs1 KO mice ( Wfs1 tm1 Koks) with a homozygous exon 8 deletion on 129S6 background were kindly provided by S

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Phosphorylated eIF2 suppresses general translation while promoting translation of the key ISR transcription factor ATF4 and its downstream targets, including FGF21 and GDF15 20,21,22

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