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When they do, their weight often rebounds
The effects of the leptin-GLP-1 interaction may be governed by intracellular signaling pathways, including those involving phosphorylated STAT3 and PTP1B.15,392 In Wistar rats, a diet high in fat was found to lead to a decrease in the ratio of OPG/RANKL, which resulted in increased bone resorption and ultimately a reduction in bone mass
-Restraint: Manufacturing complexities and high cost of biosimilars
doi: 10.15171/apb.2016.039 227 AsadiradANashibiRKhodadadiAGhadiriAASadeghiMAminianAet al
Author: Shelley Jeon, PharmD Candidate 2025, Northeastern University School of Pharmacy Reviewer: Courtney Cameron, PharmD, BCACP What data are available on weight regain after stopping GLP-1 receptor agonists