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Nevertheless, GLP-1 RAs are large peptide molecules, and placental transfer is not expected to be significant

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Although most studies suggest that GLP-1 receptor agonists promote weight loss primarily due to their inhibitory effect on food intake, other central impacts that have been described for native GLP-1 and some GLP-1 receptor agonists in rodents and humans inspire future clinical trials to explore additional mechanisms in the CNS

While CDKN2A copy number loss is a frequently observed event in both CM and MM, MM presents more CDK4 and CCND1 amplifications, which makes targeting CDK4 promising in MM

BDNF Val 66 Met and 5-HTTLPR genotype moderate the impact of early psychosocial adversity on plasma brain-derived neurotrophic factor and depressive symptoms: a prospective study