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Current literature supports GLP-1R-mediated anti-inflammatory and neuroprotective effects in the retina 43

At the tissue level, in vitro work using isolated pancreatic islets has characterised tirzepatide's effect on glucose-stimulated insulin secretion (GSIS), with multiple groups reporting that the dual-agonist produces greater cAMP accumulation in -cells than mono-agonists at matched concentrations

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It is not licensed for general prescribing

Those people may have already been at a higher risk of developing NAION, which could explain the higher numbers of the condition in this group, he says