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Currently, NICE guidance (NG49) emphasises lifestyle intervention as the cornerstone of NAFLD management, including weight loss of 710% of body weight, increased physical activity, and dietary modification

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Associations Between Weight Loss and Gastrointestinal Adverse Events on GLP-1RA Therapy While gastrointestinal adverse events that occur with GLP-1RAs are mainly mild-to-moderate and transient, occurring particularly during dose escalation, there may be concerns that GLP-1RA-mediated weight loss could be due to these effects

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