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Moreover, high levels of certain metals, like Fe, Ni, and Cu, can initiate oxidative stress by reacting with naturally occurring hydrogen peroxide to produce hydroxyl radicals [82]

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40 This mechanistic understanding highlights potential therapeutic avenues targeting ferroptosis for mitigating APAP-induced liver injury

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The BBB, composed of tightly joined endothelial cells, astrocytic end-feet, and pericytes, serves as a selective barrier that regulates the passage of substances from the bloodstream into the brain parenchyma (Oldendorf, 1971), while macromolecules such as transferrin and insulin use endothelial receptor-mediated transport (Nance et al., 2022)

Eur J Endocrinol