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Amlodipine reacts with different cellular regulators, e.g., mitogen-activated protein kinases (MAPKs), transcription factors, and cell cycle proteins, which may affect the maintenance of pancreatic -cell function and insulin sensitivity and control the cellular reply to oxidative stress and abnormal protein synthesis induced by AGEs 95

This important factor needs to be taken into consideration during patientphysician conversations when evaluating treatment options, enabling a patient-centered and personalized approach to disease management

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doi: 10.3390/ijms22147475 78 van OostveenWMde LangeECM

Cost considerations also favor micro-dosing for long-term management

[3] Evidence supporting these mechanisms in the context of IGF-1 DES specifically is largely extrapolated from IGF-1 biology and preclinical investigations rather than large-scale human clinical trials