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122 Mechanistically, mDIC mediated the influx of succinate into adipocytes, which enhanced succinate receptor 1 to inhibit lipolysis by dampening the cAMP-phosphorylated hormone-sensitive lipase pathway

Same amount of extracts were used for each ChIP experiment, followed by western blot analysis with FLAG antibody

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Of note, ectopic ACTH secretion is common in lung carcinoid tumors but is not always associated with overt cortisol excess ( 68 Ga-labeled somatostatin analog uptake in the pituitary gland, along with the elevated serum cortisol and ACTH levels at baseline, suggests that this patient had some degree of cortisol excess at baseline