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Pathway enrichment analyses of phosphosites were done using STRING ( The MS proteomics raw data and the corresponding processing reports generated in this study have been deposited in the ProteomeXchange Consortium database ( via the PRIDE (52) partner repository (PXD038649)

The observed ability of ipamorelin to influence insulin release suggests that this compound could be of research interest in the context of diabetes mellitus, particularly type 2 diabetes, where insulin secretion is impaired

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If dietary compliance is confirmed, increase to 1.5ml weekly or add a second 1ml injection mid-week

Key successes include the validation of BDNF deficits, hippocampal atrophy, and monoaminergic dysfunction as central mechanisms in human populations