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No a priori sample size was determined, however assuming that at least 1015 subjects are needed for each independent variable included in the multivariate analysis the sample size was more than sufficient to accommodate the number of co-variables examined in this investigation (see Statistical analysis paragraph)

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Use of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with acetaminophen and codeine phosphate tablets requires careful consideration of the effects on the parent drug, codeine, and the active metabolite, morphine

Furthermore, cytokines such as TNF- and interferon-gamma have been shown to induce extrinsic apoptosis in melanocytes in addition to ROS