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GHK-Cu applied to thigh skin for 12 weeks improved collagen production in 70% of women treated compared to 50% treated with vitamin C cream and 40% with retinoic acid

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A conditional Met -transgenic mouse was also generated, showing that the enhancement of MET levels in neurons selectively delays the disease onset in ALS mice models, prolonging lifespan, retarding motor neuron loss, and ameliorating motor performance (Genestine et al., 2011)

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Vitamin B6 is required as a cofactor, and serine is also used