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Certain MC1R variants reduce the capacity for repair to damaged DNA [5], while the process of melanin biosynthesis, particularly of pheomelanin, may itself generate reactive oxygen species and other by-products that may be cytotoxic, genotoxic, or mutagenic causing DNA damage [4, 6]

By improving fibroblast function and reducing wrinkle formation, IGF-1 LR3 may help maintain youthful skin and slow the visible effects of aging (10)

Its also the basis of an exploding pharmaceutical categorythink Ozempic, Wegovy, Mounjarocollectively reshaping how doctors approach obesity and diabetes

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In a separate investigation of the TriNetX database involving 15,176 propensity-score matched patients pairs with type 2 diabetes and MASLD, Kuo et al