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In a pivotal study published in the Journal of Orthopedic Research, researchers created 0.8 cm segmental bone defects in rabbit radius bones and compared healing across treatment groups

Furthermore, mutations in the juxtamembrane domain led to tumorigenesis in an in vitro trial (Graveel et al., 2013)

The anxiolytic-like effect of RES treatment is mediated by phosphodiesterase 4 (PDE4), with a downstream increase in BDNF expression in the hippocampus