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Besides releasing melatonin into the circulation in small amounts (usually levels are in the range of pg/mL), melatonin is also discharged directly into the cerebrospinal fluid (CSF) of the third ventricle and is likely an important primary secretory pathway since the nocturnal elevation in this fluid is roughly an order of magnitude greater than that in the blood ( Figure 1 ) (45)

These signaling mechanisms increase aromatase activity and LHR expression (60)

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Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last

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From in vitro studies using human SH-SY5Y neuronal cells, it was demonstrated that cell proliferation is increased with GLP-1 treatment (Li et al., 2010