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Feb 11 2020;10(2)doi:10.3390/metabo10020064

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Lipomatosis Syndromes In studies conducted in 2016-2018, a pathogenic variant in the MFN2 gene that encodes mitofusin 2, a membrane-bound mediator of mitochondrial membrane fusion and inter-organelle communication, have been reported to be associated with partial lipodystrophy, upper body adipose hyperplasia, and suppression of leptin expression (171) (Fig.15)

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