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In Vivo Study Taking into consideration the results from the series of screening studies above, Compound 1.70 was selected for in vivo study as it showed retention in activity with all of the key enzymes (GST, GPx, and GR) while also displaying improved stability, as opposed to the other compounds that had lost activity with one or more key enzymes

BioMed Res Int 2017:4862861

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after a case of a nondiabetic, nonobese patient with unexpected regurgitation of a large volume gastric content, despite a 20-hour solid and an 8-hour liquid fasting liquid [7]

Pharmaceutical Strategies to Make Better Drugs for Nonalcoholic Fatty Liver Disease Therapy

J Pharmacol Exp Ther 1986