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As a practical guide: if gastrointestinal symptoms persist beyond two to four weeks at a stable dose, are significantly affecting your ability to eat, drink, or carry out daily activities, or are causing signs of dehydration, you should contact your prescriber rather than waiting for symptoms to resolve on their own

Imaging must now account for therapeutic weight loss as an expected variable, not an anomaly

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However, the phase 3 global study (REGENERATE) interim analysis at 18 months reported rapid and sustained improvements in liver enzymes and stiffness with OCA (25 mg qd) treatment

Increasing the pH of the 2 M urea buffer from 8.5 to 10.5 substantially increased the proportion of solubilised Trx-mGH protein (Fig

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