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and in the SUSTAIN 6 trial, a 36% reduction was reported in the occurrence of this end point [21]

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In a Phase 2 obesity trial of retatrutide published in the New England Journal of Medicine in 2023, nausea, diarrhea, vomiting and constipation were cited as the most common adverse events, with higher doses associated with more severe problems

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In both cases, a very small number