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Early Subthreshold Aerobic Exercise for Sport-Related Concussion: A Randomized Clinical Trial

Benefits: Improves circadian rhythm by promoting the delta rhythm, achieved in Stage 4 of sleep (the stage when Growth Hormone is made) Antioxidant effect in the brain via increases in glutathione peroxidase and superoxide dismutase Increased alertness, improved stress tolerance, and coping behavior during awake cycles Restoration of slow-wave sleep in Cushings Syndrome Possible anticonvulsant action by increasing the threshold to NMDA- and picrotoxin-induced convulsions Increase in testosterone levels when treating with DSIP alone (100-200 point increases have been observed) Side Effects: Potential to disrupt sleep

Evening (pre-bed): Most common timing, as it supports natural GH rhythm and enhances sleep quality

Gonzlez-Porto, A

Others have something specific in mind, like immune support before a flight, recovery after a tough event, or hangover help

2023;83:39319.e5