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N Engl J Med 2008;358:999-1008

Subcutaneous injections should be administered correctly, rotating injection sites to prevent lipohypertrophy (thickening of fatty tissue), which can impair drug absorption

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These upcoming trials represent only a fraction of the nationwide litigation, where thousands of claims remain pending, and jury verdicts have already reached into the billions

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The most common adverse reactions reported in clinical trials include gastrointestinal symptoms (nausea, vomiting, diarrhea, constipation), which occurred in a substantial proportion of patients but are generally transient