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R Met/Met individuals have higher synaptic dopamine and norepinephrine (because COMT clears them more slowly), which improves prefrontal cortex function and working memory but increases susceptibility to stress-related anxiety, pain sensitivity, and catechol estrogen accumulation

Dietary and lifestyle practices can support the bodys natural glutathione production

Although the liver is recognised as a major site of metformin pharmacodynamics, recent evidence also implicates the gut as an important site of action

[DOI] [PubMed] [Google Scholar] 29.Zhou J, Yi X, Li Y, Ding Y

The third term is the rate of production of oxidized GSSG from GSH via the enzyme GPX and the fourth term is the conversion of GSSG back to GSH via the enzyme GR

HRT doesnt directly cause weight loss, but it restores the hormonal baseline needed for better metabolic health