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doi:10.1016/j.enzmictec.2007.10.008 Liang G, Du G, Chen J (2008b) Enhanced glutathione production by using low-pH stress coupled with cysteine addition in the treatment of high cell density culture of Candida utilis

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We also added low levels of diacetyl (0.12 M) to the Buffer solution to reduce the effect of possible abrupt changes in diacetyl concentration that would greatly impact AWA activity

Additionally, PARP inhibitors (PARPi) demonstrate significant clinical efficacy in BRCA-mutated patients (124), but emerging resistance limits their long-term effectiveness (125), Patients may develop resistance through multiple mechanisms, such as secondary BRCA gene mutations or restoration of DNA repair pathways (126)