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Depression and anxiety in inflammatory bowel disease: epidemiology, mechanisms and treatment

Androgens have a direct inhibitory effect on the classical Wnt/-catenin pathway, leading to miniaturization of hair follicles and hair loss [31, 32]

What this could mean for clinics, compounders, and patients There are three plausible near-term outcomes

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PanCK stain was performed in an attempt to identify cholangiocytes, however high background stain from hepatocytes did not allow this, likely due to hepatocytes transdifferentiation and expression of cholangiocyte markers under cholestasis and liver damage conditions 11,12

Clinical judgement and individualised assessment are essential when considering any pharmacological intervention