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With aging of MS, peripheral immune-mediated inflammation subsides and WM lesions evolve either into inactive plaques that only have sparse immune cells present or alternatively smoldering lesions that have a demyelinated core with a rim of activated microglia along the lesion edge in close proximity to lymphocytic perivascular cuffs (alternatively referred to as chronic-active or mixed active/inactive lesions)

Spyridon Konstantinidis and Murphy Poplyk for polishing chromatography development

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European journal of case reports in internal medicine

Down-regulation of human osteoblast PTH/PTHrP receptor mRNA in end-stage renal failure