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The three practical cash-pay routes are Lilly Direct self-pay (FDA-approved Zepbound vials and KwikPen, roughly $349$499/mo depending on dose), retail pharmacy without insurance (about $1,086/mo at list price rarely viable), and compounded tirzepatide through a licensed telehealth provider

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According to Truveta Research presented at ISPOR 2025, side effects were the leading reason patients stopped taking GLP-1 medications, accounting for 28.2% of all discontinuations