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The structural modifications of the analogs with the best XO inhibition values, with satisfactory IC 50 values, with changes of the groups in 3CF 3 C 6 H 4 and 4iPrOC 6 H 4 , and variations in the same position, 6, with the H, COOC 2 H 5 , and COOH groups (Figure 13)

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Clegg LE, Penland RC, Bachina S, Boulton DW, Thuresson M, Heerspink HJL, et al

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doi: 10.1158/1055-9965.EPI-13-1057 5 WangJPSunYHBertagnolliMM